iu.i2sysbio@uv.es (+34) 963 544 810

Introduction and objective

Joint research center of the University of Valencia and the Spanish National Research Council (CSIC), founded in 2016.

Introduction and objective

It is an institute open to the strategic participation of biotechnology companies. Its scientific programs focus on research on the structure, function, dynamics, evolution and manipulation of complex biological systems.

It aims to provide solutions to problems in the pharmaceutical, biotechnological, biomedical and agro-industrial sectors that are open to a systemic approach.

Main research programs

The research groups at ISysBio are organized thematically into five Scientific Programs (SP). These programs are dynamic and evolve to incorporate new research and developments in integrative systems biology.


  • logoTheoretical and Computational Biology
  • logoSystems Biology of Molecular Interactions and Regulation
  • logoSystems Biology of Pathogens
  • logoEvolutionary Systems Biology of Symbionts
  • logoApplied Systems Biology and Synthetic Biology
  • logoInnovation Unit (Synbiosis)

Institute for Integrative Systems Biology (UV + CSIC) news

A research group led by I2SysBio develops a new computational tool to investigate genome complexity
I2SysBio research team creates VIPERA, a software that evaluates how SARS-CoV-2 evolves throughout the infection
I2SysBio coordinates a platform to offer R+D+i resources in Computational Biology and Bioinformatics
The Institute of Integrative Systems Biology (I2SysBio), pioneer in therapies against multi-resistant bacteria to antibiotics
I2SysBio team describes for the first time the mechanisms of plants to fight against viroids, the smallest known infectious agents
A team from I2SysBio participates in a study that uses plants to create nanoparticles with antibodies against SARS-CoV-2

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